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KMID : 0882420170920030277
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Korean Journal of Medicine
2017 Volume.92 No. 3 p.277 ~ p.285
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Analysis of Adverse Drug Reactions in Elderly Patients Based on a Spontaneous Reporting System in a Single Tertiary Hospital
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Lim Kyung-Whan
Kang Min-Koo
Kim Byung-Keun
Kim Ju-Young
Kang Min-Gyu
Park Han-Ki
Kang Hye-Ryun
Cho Sang-Heon
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Abstract
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Background/Aims: Several factors contribute to the greater propensity for adverse drug reactions (ADRs) in the elderly, including the use of multiple drugs and pharmacokinetic and pharmacodynamic alterations due to aging. We evaluated the characteristics of ADRs in elderly versus younger adults.
Methods: ADRs were collected from a spontaneous reporting system at Seoul National University Hospital from February 2010 to September 2013. We analyzed causative drugs, clinical manifestations, and the severity of ADRs.
Results: In total, 15,541 ADRs were reported in patients 18 years of age or older. Common causative drug categories included nervous system, anti-neoplastics, and anti-infectives. The prevalence of ADRs due to respiratory drugs and cardiovascular drugs was higher in the elderly group (≥ 60 years) than in other groups. The most common clinical types were gastrointestinal and skin and appendage issues. The elderly group had a tendency to show a higher proportion of psychiatric, cardiovascular, hematological, and genitourinary symptoms. The proportions of severe ADRs were higher in the elderly groups and in male patients.
Conclusions: Elderly patients were susceptible to ADRs related to respiratory and cardiovascular drugs. Psychiatric, cardiovascular, hematological, and genitourinary disorders account for a higher proportion of ADR symptoms in the elderly than in other age groups. Further efforts to understand, manage, and prevent ADRs in the elderly are required.
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KEYWORD
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Drug-related side effects and adverse reactions, Pharmacovigilance, Aged
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